A kind of analgesic composition includes insulin analog and blend polymer. The insulin analog includes that the cysteine at the place position B4 and A10 replaces (form cystine B4-A10) and the additional displacement of one or more selected from the following: between INSULIN A-and B structure domain the connection structure domain of 5-11 amino acid Non-beta branched chain amino acid displacement at the A8 of position Non-beta branch acidity or polar side chain at the A14 of position The ortho position halogen of PheB24 is modified And the lysine at the B29 of position is replaced by Glu, Ala, Val, Ile, Leu, alanine, aminobutyric acid or nor-leucine. Insulin analog with include that the manufacturing process of one or more steps in 90-120 DEG C of temperature range is compatible. The insulin analog of packing can optionally include Free PEG or PEGylated. The blend polymer of insulin analog packing may be cast as the microneedle patch for administering locally to or for hypodermic pellet.
