A kind of analgesic composition, including insulin analog and blend polymer.The insulin analog includes that the cysteine at the place position B4 and A10 replaces (form cystine B4 A10) and the additional displacement of one or more selected from the following:The connection structure domain of 5 11 amino acid between INSULIN A and B structure domain;Non-beta branched chain amino acid displacement at the A8 of position;Non-beta branch acidity at the A14 of position or polar side chain;PheB24The modification of ortho position halogen;And the lysine at the B29 of position is replaced by Glu, Ala, Val, Ile, Leu, alanine, aminobutyric acid or nor-leucine.Insulin analog with include that the manufacturing process of one or more steps in 90 120 DEG C of temperature range is compatible.The insulin analog of packing can optionally include Free PEG or PEGylated.The blend polymer of insulin analog packing may be cast as for administering locally to microneedle patch or be used for hypodermic pellet.
