ALTENBACH, ROBERT J.,BOGDAN, ANDREW,COWART, MARLON D.,ESMIEU, WILLIAM RAMESH,GFESSER, GREGORY A.,GRESZLER, STEPHEN N.,KOENIG, JOHN R.,KYM, PHILIP R.,LIU, BO,MALAGU, KARINE FABIENNE,PATEL, SACHIN V.,SC
申请号：
CA2991273
公开号：
CA2991273A1
申请日:
2016.07.14
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides for compounds of formula (I) wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
