您的位置: 首页 > 农业专利 > 详情页

Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders
专利权人:
DiscoveryBioMed; Inc.
发明人:
Schwiebert, Erik,Streiff, John,Dixon, John,Gao, Hongwu
申请号:
AU2014240026
公开号:
AU2014240026A1
申请日:
2014.03.14
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis and chronic obstructive pulmonary diseases). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充