592685 Disclosed is a compound of formula (I) which is an azabicyclic substituted on a phenyl group which in turn is substituted on a dihydroquinoline. Examples of compounds of formula (I) are: N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2- (trifluoromethyl)phenyl)-4-oxo-5-( trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide； N-(4-(7-azabicydo[2.2.1]heptan-7-yl)-2-cyanophenyl)-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide and N-[4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(3-dimethylaminoprop-1-ynyl)phenyl]-4-oxo-5-(trifluoromethyl)-1H -quinoline-3-carboxamide. Also disclosed are pharmaceutical compositions and kits comprising a compound of formula (I) Further disclosed is the use of a compound of formula (I) in the manufacture of a medicament for the treatment of diseases such as cystic fibrosis, COPD, liver diseases and Alzheimer's disease.
