Holmes, Ian Peter,Watson, Stephen Paul,Martin, Stephen Lewis,Gaines, Simon
申请号：
AU2011202994
公开号：
AU2011202994B2
申请日:
2011.06.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011202994B220120816.pdf#####Abstract The present invention comprises compounds of Formula (1): R-- Z- Q -X>； Y A 8 D E R' R R3 R2 (1) Wherein: A represents bond, C1.ealkyl or CH=CH-C,.4 alkyl； B represents bond, 0, S, SO, SO2, CO, CRR', C0 2R14, CONR 4R1 , N(COR' 4)(COR"), N(S0 2R14)(COR'") or NR' 4R1 ； D represents bond, or C1.6alkyl； E represents substituted aryl or substituted or unsubstituted heteroaryl； Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring； X represents 0, S, SO, S02, CO, CNR , CNOR', CNNR R', NR" or CRR； Y represents CR5OR", CR5SR", NOR', CR'NR*R", SO, SO 2 , CO, CNR', CNOR' or CS； R' and R" each independently represents H, C1.ralkyl or C1.4alkylaryl； R2 represents CO2R', CH2OR" or CONR R", CONROR", NR"COR , SR", PO(OH)2 , PONHR' 2 or SONHR12； R3 represents H, C1.6alkyl or C1.alkylaryl； R4 represents optionally substituted aryl or heteroaryl； Z represents a bond, CH 2, 0, S, SO, S02, NR5, OCR5 R6 , CR9R'00 or Z, R4 and Q together form an optionally substituted fused tricyclic group； R' and R6 each independently represent H, C1.6 alkyl or C1.4 alkylaryl； R7 and R8 each independently represent H, halo, C1.6 alkyl or C1. alkylaryl； R9 and R10 each independently represents H, C1.6 alkyl optionally substituted by halo, cyano, OR" or NR6R" , C1.4 alkylaryl optionally substituted by halo, cyano, OR11 or NR6R", OR" or, together with the N to which they are attached, R9 and R' form a heterocyclic group: R" represents H, C1.e alkyl, C1.4 alkylaryl or COR5； R12 and R13 each independently represent H, C1.3 alkyl, C1.3 alkylaryl or C1.3 alkylheteroaryl or, together with the functionality to which they are attached, R12 and R" form a heterocyclic group: R14 and R15 each independently represent H, C1.6 alkyl, C1.4 alkylaryl or C1.4 alkylheteroaryl or together with the functionality to which they are attached R14 and R'5 form a heterocyclic or fused heterocycl
