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Binary compounds as ATX inhibitors
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
PETRA SCHMITZ,DANIEL HUNZIKER,PATRICK DI GIORGIO,MARKUS RUDOLPH,JRME HERT,PATRIZIO MATTEI
申请号:
ARP160102899
公开号:
AR106118A1
申请日:
2016.09.23
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
Compositions containing the compounds and methods of use of said compounds. Claim 1: Compounds of the formula (1) wherein: R¹ is substituted phenyl, substituted C₁₋₆ phenyl-alkyl, substituted C₁₋₆-phenoxy-alkyl, substituted C fen-phenyl-alkenyl, substituted-C₂₋₆-alkynyl , substituted pyridinyl, substituted C₁₋₆ pyridinyl-alkyl, substituted C₂₋₆ pyridinyl-alkenyl, substituted C₂₋₆-pyridinyl-alkynyl, substituted thiophenyl, substituted C₁₋₆-thiophenyl-alkyl, substituted C--thiophenyl-alkenyl or thiophenyl-alkynyl C₂₋₆ substituted, said substituted phenyl, substituted C₁₋₆ phenyl-alkyl,substituted C₁₋₆-phenoxy-alkyl, substituted C₂₋₆-phenyl-alkenyl, substituted C₂₋₆-phenyl-alkynyl, substituted pyridinyl, substituted C₁₋₆-pyridinyl-alkyl, substituted-C,-pyridinyl-alkenyl, substituted-C₂₋₆-pyridinyl-alkynyl , substituted thiophenyl, substituted thiophenyl-C₁₋₆-alkyl, substituted thiophenyl-C-alkenyl and substituted thiophenyl-Cin-alkynyl are substituted by R³,R830808 and r83099;This is a - OC (o) - O-C (o) -;W is - C (o)-S (O) o -CR R -R 2 was selected from the formula groups B, F, l, m, O, Z, AF, Ag, ah, AJ, an, Ao, AP, AQ, AR, as, at, Au, AV, ax, ay, AZ, AZ, Ba, BC and BD (2);R3: halogen, hydroxy, cyanogen, hydrocarbyl c83321c831832626;C₁₋₆ alkoxy,(alcoxi c83321218c83316262) - rent for c83218c83316262,C₁₋₆ haloalkoxy,C₁₋₆ haloalkyl,C₁₋₆ hydroxyalkyl,C₃₋₈ cycloalkyl,(C₃₋₈ cycloalkyl) -C₁₋₆ alkyl,(C₃₋₈ cycloalkyl) -C₁₋₆ alkoxy,C₃₋₈ cycloalkoxy,(cycloalcoxi c83223-83318328na) - asphalt c8321c833312626;Lease c8332121;(C₁₋₆ alkyl) -carbonylamino, (C₃₋₈ cycloalkyl) -carbonyl-amino, (C₁₋₆ alkyl) -tetrazolyl, (C₁₋₆ alkyl) -tetrazolyl-C₁₋₆ alkyl or heterocycloalkyl-C₁₋₆ alkoxy;R⁴ and R⁵ are independently selected from H, halogen, hydroxy, cyano, C₁₋₆ alkyl,C₁₋₆ alkoxy,(alcoxi c83321218c83316262) - rent for c83218c83316262,C₁₋₆ haloalkoxy,C₁₋₆ haloalkyl,hydroxy-C₁₋₆ alkyl,C₃₋₈ cycloalkyl,(C₃₋₈ cycloalkyl) -C₁₋₆ alkyl,(C₃₋₈ cycloalkyl) -C₁₋₆ alkoxy,C₃₋₈ cycloalkoxy,(cycloalcoxi c
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