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8 - CARBAMOYL - 2 - (2,3- DI SUBSTITUTED PYRID - 6 - YL) -1,2,3,4 -TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS - INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
专利权人:
ABBVIE INC.
发明人:
WANG, LE,DOHERTY, GEORGE,WANG, XILU,TAO, ZHI-FU,BRUNKO, MILAN,KUNZER, AARON R.,WENDT, MICHAEL D.,SONG, XIAOHONG,FREY, ROBIN,HANSEN, TODD M.,SULLIVAN, GERARD M.,JUDD, ANDREW,SOUERS, ANDREW
申请号:
SG11201401279X
公开号:
SG11201401279XA
申请日:
2012.10.11
申请国别(地区):
SG
年份:
2014
代理人:
摘要:
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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