8 - carbamoyl - 2 - (2,3- di substituted pyrid - 6 - yl) -1,2,3,4 -tetrahydroisoquinoline derivatives as apoptosis - inducing agents for the treatment of cancer and immune and autoimmune diseases
Wang, Le,Doherty, George,Wang, Xilu,Tao, Zhi-Fu,Brunko, Milan,Kunzer, Aaron R.,Wendt, Michael D.,Song, Xiaohong,Frey, Robin,Hansen, Todd M.,Sullivan, Gerard M.,Judd, Andrew,Souers, Andrew
申请号：
AU2012322698
公开号：
AU2012322698A1
申请日:
2012.10.11
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl； Y
