Subjects of the invention are a method of plasminogen supplementation in a plasminogen-deficient subject, and method for the treatment of plasminogen-deficiency in a plasminogen-deficient subject. These methods comprise administering to the plasminogen-deficient subject a repeated dose of plasminogen, and more particularly Glu-plasminogen, for increasing the subject plasminogen activity level by at least about 1%, and more particularly by at least about 10%, of the normal plasminogen activity and for maintaining said increased plasminogen activity level over a supplementation period or a treatment period. The plasminogen-deficient subject of the present invention may suffer from Type-I, Type-II plasminogen-deficiency or an acquired deficiency.本發明之主題為一種在缺乏纖維蛋白溶酶原之個體中補充纖維蛋白溶酶原之方法，及用於治療缺乏纖維蛋白溶酶原之個體之纖維蛋白溶酶原缺乏症的方法。此等方法包括向該缺乏纖維蛋白溶酶原之個體投與重複劑量之纖維蛋白溶酶原，及更尤其Glu-纖維蛋白溶酶原，以在補充時期或治療時期內使該個體纖維蛋白溶酶原活性水準增加正常纖維蛋白溶酶原活性之至少約1%且更尤其至少約10%，且維持該增加之纖維蛋白溶酶原活性水準。本發明之缺乏纖維蛋白溶酶原之個體可罹患I型、II型纖維蛋白溶酶原缺乏症或獲得性缺乏症。
