YINGJUN ZHANG,XIAOJUN WANG,JI ZHANG,FACHENG MA,CHANGWEI HUANG,XINYE YANG
申请号：
ARP160102677
公开号：
AR105893A1
申请日:
2016.09.01
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Replace (non) arilo derivatives with carbohydrates and pharmaceutical compounds containing these compounds. Drug compounds or compounds are useful for the inhibition of diazepam oxidase and uric acid anion 1 carrier. 2. Use of these pharmaceutical compounds and ingredients in the treatment or prevention of diseases related to high concentrations of uric acid in mammals, especially in human blood； Property 1: a compound with the properties of formula (1) or stereoisomer, geometric isomer, tautometer, positive oxide, hydrate, solution, metabolite and ester,1. Pharmaceutically acceptable or degradable salts, in which u is phenyl or isobutylene with 5 to 6 members； each R1 and R2 is independent h, D, halogen；No.8322；CN, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；haloalkyl C₁₋₆,C₁₋₆ alkoxy,haloalkoxy C₁₋₆,alquil C -amino haloalquil C -amino cicloalquilo de 3 a 8 miembros o heterociclilo de 3 a 8 miembros en donde cada uno del alquilo CC₂₋₆ alkenyl,1. C 83228331 asphalt；haloalkyl C₁₋₆,C₁₋₆ alkoxy,haloalkoxy C₁₋₆,C₁₋₆-amino alkyl, C₁₋₆-aminoalkyl-alkyl, 3-8 membered cycloalkyl or 3-8 membered heterocyclyl is, independently, and is optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (= O),NH.8322；O cn no.832222； t is h, D, F, Cl, Br, no.832222；c) Yes.X is CR⁴ or N； R⁴ is H, D, halogen, C₁₋₆ alkyl,haloalkyl C₁₋₆,C₁₋₆ alkoxy,C₁₋₆-alkyl or C₁₋₆-haloalkoxy；each of Y and Z is independently C, CH or N； "⁻ ⁻ ⁻ ⁻ ⁻" Refers to a single bond or a double bond； Q is pheno, carbocycle C₄₋₇,4-7 member heterocycles or 5-6 member heteroaromatic rings； each cubic meter is an independent h, D, halogen, oxo (= O),Oh, nh832222,No.8322；CN, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；haloalkyl C₁₋₆,C₁₋₆ alkoxy,haloalkoxy C₁₋₆,C₁₋₆-alkyl, C₁₋₆-amino haloalkyl, 3-8 membered cycloalkyl, 3-8 membered heterocyclyl, 5-10 membered heteroaryl, phenyl, naphthyl or G, where each of C del alkyl ,C₂₋₆ alkenyl,1. C 83228331 asphalt；haloalkyl C₁₋₆,C₁₋₆ alkoxy,haloalkoxy C₁₋₆,C₁
