DODD, Stephanie Kay,FURET, Pascal,GROTZFELD, Robert Martin,JONES, Darryl Brynley,MANLEY, Paul,MARZINZIK, Andreas,PELLE, Xavier Francois Andre,SALEM, Bahaa,SCHOEPFER, Joseph,JAHNKE, Wolfgang
申请号:
CY181100518
公开号:
CY1120235T1
申请日:
2018.05.18
申请国别(地区):
CY
年份:
2019
代理人:
摘要:
The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.