INHIBITEUR DE LA PRODUCTION DE MÉLANINE, AGENT D'ÉCLAIRCISSEMENT DE LA PEAU, ACTIVATEUR DES FIBROBLASTES, PROMOTEUR DE LA PRODUCTION DU COLLAGÈNE ET/OU DE L'ÉLASTINE, ET AGENT D'AMÉLIORATION DES RIDES
The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]
