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MODULATEURS ALLOSTERIQUES POSITIFS DU RECEPTEUR MUSCARINIQUE DE L'ACETYLCHOLINE M4
- 专利权人:
- VANDERBILT UNIVERSTIY
- 发明人:
- LINDSLEY, CRAIG W.,CONN, P. JEFFREY,ENGERS, DARREN W.,BOLLINGER, SEAN,TARR, JAMES C.,SPEARING, PAUL,ENGERS, JULIE L.,LONG, MADELINE,BRIDGES, THOMAS M.
- 申请号：
- CA3026578
- 公开号：
- CA3026578A1
- 申请日:
- 2017.06.22
- 申请国别(地区):
- CA
- 年份:
- 2017
- 代理人:
- 摘要：
- Disclosed herein are tricyclic compounds,including pyrimido [4',5': 4 ,5 ]thieno [2,3 -c]pyridazine- 8 -amine, pyrido [3',2M,5]thieno [3 ,2 -d]pyrimidine-4-amine,pyrazino [2',3' :4 ,5 ]thieno [ 3,2-d]pyrimidin-4 -amine,pyrido[3',2':4,5]furo[3,2-d]pyrimidin-4- amine, andpyrimido[4',5':4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be usefulas positive allosteric modulators of the muscarinic acetylcholine receptor M4(mAChR M4). Also disclosed herein are methods ofmaking the compounds, pharmaceutical compositions comprising the compounds,and methods of treating neurological and psychiatricdisorders associated with muscarinic acetylcholine receptor dysfunction usingthe compounds and compositions.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
