LINDSEY, Craig W.,CONN, P. Jeffrey,ENGERS, Darren W.,BOLLINGER, Sean,TARR, James C.,SPEARING, Paul,ENGERS, Julie L.,LONG, Madeline,BRIDGES, Thomas M.
申请号：
PH12018502638
公开号：
PH12018502638A1
申请日:
2018.12.13
申请国别(地区):
PH
年份:
2019
代理人:
摘要：
Disclosed herein are tricyclic compounds, including pyrimido[4',5':4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3',2M,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2',3':4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3',2':4,5]furo[3,2- d ]pyrimidin-4- amine, and pyrimido[4',5':4,5]furo[2,3- c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
