Craig W. Lindsley,P. Jeffrey Conn,Darren W. Engers,Carrie K. Jones,Thomas M. Bridges,Changho Han,Andrew S. Felts
申请号：
US15661786
公开号：
US20180028501A1
申请日:
2017.07.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are thieno[3,2-e][1,2,4]triazolo[1,5-a]pyridin-6-amine, thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridin-3-amine, and imidazo[1,2-a]thieno[3,2-e]pyridin-3-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
