BOLLINGER, Sean,BRIDGES, Thomas M.,CONN, P. Jeffrey,ENGERS, Darren W.,ENGERS, Julie L.,LINDSLEY, Craig W.,LONG, Madeline,SPEARING, Paul,TARR, James C.
申请号：
TN2018000416
公开号：
TN2018000416A1
申请日:
2017.06.22
申请国别(地区):
TN
年份:
2020
代理人:
摘要：
Disclosed herein are tricyclic compounds, including pyrimido[ 4',5':4,5 ]thieno[2,3- c ]pyridazine-8-amine, pyrido [3 ',2': 4 ,5 ]thieno [ 3 ,2-d]pyrimidine-4-am ine, pyrazino[2' ,3' :4,5]thieno[3 ,2-d]pyrimidin-4-amine, pyrido[3' ,2' :4,5] furo[ 3, 2-d]pyrimidin-4- amine, and pyrimido[4',5':4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatrie disorders associatcd with muscarinic acetylcholine receptor dysfonction using the compounds and compositions.
