Solid oral composition comprises agomelatine or its hydrate, complexes, co-crystals, crystalline forms, addition salts with an acid or a base, and one or more excipients comprising diluents, binders, flowing agents, lubricants, coating agents, plasticizers, flavors, anti-irritants or sweeteners, where the composition has: an absolute bioavailability of greater than 25%； and a bioavailability greater than that obtained for an orodispersible tablet with an oromucosal absorption containing the active principle agomelatine under the same form and at the same dosage. ACTIVITY : Antidepressant； Tranquilizer； Neuroleptic； Hypnotic； Cardiovascular-Gen.； Gastrointestinal-Gen.； CNS-Gen.； Muscular-Gen.； Anorectic. MECHANISM OF ACTION : None given.L'invention a pour objet une composition pharmaceutique buccale solide contenant de l'agomélatine destinée à une action systémique.
