PROBLEM TO BE SOLVED: To provide an olmesartan medoxomil-containing pharmaceutical composition in which a decomposition reaction during storage of a formulation containing olmesartan medoxomil as an active ingredient is suppressed compared to conventional products.SOLUTION: A pharmaceutical composition contains following components (A)-(C). (A) Olmesartan medoxomil, (B) one or more kinds of highly water absorbing property additives selected from a binder, a disintegrator and an excipient, wherein the additives contain water at a water absorption rate of not less than 3%, and a total content of the (B) is 70 mass% or more of a content of the (A), and (C) non water absorbing property additives selected from a binder, a disintegrator, and an excipient, wherein the additives contain water at a water absorption rate of less than 1%, and a total content of the additives (C) is 80 mass% or less of the total content of the (B), are contained in the pharmaceutical composition.COPYRIGHT: (C)2015,JPO&INPIT【課題】主薬であるオルメサルタンメドキソミルの製剤保存中における分解反応が、従来品より抑制されたオルメサルタンメドキソミル含有医薬組成物を提供することを課題とする。【解決手段】(A)オルメサルタンメドキソミル、及び(B)結合剤、崩壊剤、及び賦形剤から選択される添加物であって、吸水率が3%以上の高吸水性添加物の1種以上を含み、前記(B)の総含有量が、前記(A)の含有量の70質量%以上であり、(C)結合剤、崩壊剤、及び賦形剤から選択される添加物であって、吸水率が1%未満の非吸水性添加物の総含有量が、前記(B)の総含有量の80質量%以下であることを特徴とする医薬組成物。【選択図】 なし
