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COMPOSES ANTAGONISTES DU CALCIUM DE TYPE DIHYDROPYRIDINE, PROCEDES DE PREPARATION ET UTILISATIONS MEDICALES DE CES COMPOSES
专利权人:
COSUNTER PHARMACEUTICAL COMPANY
发明人:
CHEN, GUO-HUA,WANG, LI
申请号:
CA2712619
公开号:
CA2712619C
申请日:
2009.01.05
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
Dihydropyridine calcium antagonist compounds, preparation methods and medicaluses thereof are disclosed.Particularly, preparation methods of compounds of general formula (I) and (II)and pharmaceutically acceptable salts thereof,and their uses in the treatment of cardiovascular diseases are disclosed,wherein R1 represents substituted or unsubstitutedheterocyclic, aromatic ring or aralkyl group, the substituents may be C1-C4alkyl, C1-C4alkoxyl, halogen, cyano, trifluoromethyl,trifluoromethoxyl, methylthio, nitro, amino or hydroxyl; R2 represents C1-C8alkyl; R3 and R4 may be same or different,and each independently represents hydrogen, halogen, cyano, trifluoromethyl,trifluoromethoxyl, methylthio, nitro, amino orC1-C4alkyl, C1-C4alkoxyl, C1-C4alkenyl, C1-C4alkynyl; R5 and R6 are same ordifferent, and each represents C1-C4alkyl; Xrepresents O, S or a single bond; m=0-6, n=1-6, and m and n may be same ordifferent.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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