GALLEY, GUIDO,GOERGLER, ANNICK,GROEBKE ZBINDEN, KATRIN,NORCROSS, ROGER,STALDER, HENRI
申请号：
ES07821039
公开号：
ES2381589T3
申请日:
2007.10.09
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
The use of a compound of the formula R4 R2 in which R1 is hydrogen, C1-7 alkyl, - (CR2) n-OH, - (CH2) n-aryl or - (CH2) n-heteroaryl, which are optionally substituted by halogen, C1-7 alkoxy or C1-7 alkyl substituted by halogen, or is - (CR2) n-C3-7 cycloalkyl, optionally substituted by hydroxy, - (CH2) n-heterocyclyl, - (CH2) n-NH- S (O) 2CH3 or is - (CR2) nO-C1-7 alkyl or C1-7 alkyl substituted by halogen； R is hydrogen or C1-7 alkyl, and when two R groups are present, they may be the same or not； R2 is 2,2-dioxo-2,3-dihydro-1H-benzo [c] thiophenyl, 6,7-dihydro-5H-cyclopentapyrimidin-2-yl, 2,2-difluor-benzo [1,3] dioxol- 5-yl, 2, 2, 3, 3-tetrafluor-2, 3-dihydro-benzo [1,4] dioxin-6-yl, or is aryl or heteroaryl, optionally substituted by one or more substituents, chosen from the group formed by halogen, C1-7 alkyl, C3-7 cycloalkyl, - (CH2) nhydroxy, halogen substituted C1-7 alkyl, halogen substituted C1-7 alkoxy, -S (O) 2-C1-7 alkyl, - ( CH2) nS (O) 2-NH-C1-7 alkyl, - (CH2) nO-C1-7 alkyl, nitro, amino, cyano, -NHC (O) -C1-7 alkyl, -C (O) NH C1-alkyl -7 or O-tetrahydro-naphthalenyl, or are substituted by - (CH2) n-aryl optionally substituted by halogen, or by -CH = CH-aryl optionally substituted by halogen, or by - (CH2) nO-aryl optionally substituted by halogen, C1-7 alkoxy or C1-7 alkyl substituted by halogen, or by O- (CH2) n-aryl optionally substituted by halogen, or by - (CH2) n-heteroaryl, or by - (CH2) nO-heter oaryl, or by - (CH2) n-heterocyclyl optionally substituted by = O, or by - (CH2) nO-heterocyclyl optionally substituted by C1-7 alkyl, or by -S-aryl, -CH (OH) -aryl, - C (CH3) 2-aryl, -NR-aryl, or by 2-oxo-2H-pyridin-1-yl； R3 is hydrogen or C1-7 alkyl； R4 is hydrogen or C1-7 alkyl； n is 0, 1, 2, 3 or 4； and its pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms thereof, and 4-phenylaminomethyl-imidazole benzyl- (3 H -imidazol-4-ylmethyl) -phenyl-amine (1 H -imidazol-4) dihydrochloride -ylmethyl) - (4-meth
