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Urea Compounds and Their Use as FAAH Enzyme Inhibitors
专利权人:
BIAL-PORTELA & Cª; S.A.
发明人:
Laszlo Erno Kiss,Rita Gusmão De Noronha,Carla Patrícia Da Costa P Rosa,Rui Pinto
申请号:
US14908696
公开号:
US20160166560A1
申请日:
2014.08.01
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A compound having Formula I:wherein: R1 is selected from hydrogen, halogen, hydroxyl and C1-4 alkoxy; R2 is selected from hydrogen, halogen, hydroxyl and C1-4 alkoxy; R3 is C1-4 alkyl; R4 is aryl which is substituted with a group selected from OSO2NH2, NHCONH2, NHSO2NH2, NHSO2C1-4 alkyl and CONH2; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; provided that the compound is not N-(1-benzylpiperidin-4-yl)-N-methyl-4-(4-(sulfamoylamino)phenyl)-1H-imidazole-1-carboxamide or N-(1-benzylpiperidin-4-yl)-N-methyl-4-(3-(methyl sulfonamido)phenyl)-1H-imidazole-1-carboxamide. The compound may be used as an inhibitor of fatty acid amide hydrolase.
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