To provide: a vesicle composition which has excellent long-term stability and penetration into the skin, while exhibiting excellent skin compatibility during use； and an external preparation for the skin and a cosmetic preparation, each of which contains the vesicle composition. A vesicle composition which contains the following components (A)-(D). (A) a phospholipid (B) one or more substances selected from among cholesterol and phytosterols (C) a cationic surfactant (D) a polypeptide mainly comprising a basic amino acid An external preparation for the skin and a cosmetic preparation, each of which contains this vesicle composition.
