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-2- -/-2- INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES
专利权人:
에프. 호프만-라 로슈 아게
发明人:
브루너 다니엘라,힐퍼트 한스,콜체브스키 사비네,림베르그 안야,말버그 제시카,프린쎈 에릭,리머 클라우스,산카르 바바니 지,스톨 테오도르
申请号:
KR1020167001441
公开号:
KR1018115490000B1
申请日:
2014.06.16
申请国别(地区):
KR
年份:
2017
代理人:
摘要:
The present invention also relates to the use of 2-oxo-2,3-dihydro-indole of formula (I) as well as its pharmaceutically acceptable salts, racemic mixtures, or the corresponding enantiomers and / or optical isomers and / or stereoisomers thereof It is about: I In this formula, Ar is a heteroaryl group containing 1, 2 or 3 heteroatoms selected from N, O or S; R 1 is hydrogen, lower alkyl, halogen, amino, dimethylamino, cyano, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, CH (OH) CF 3, (CH 2) o - lower alkoxy, optionally a heterocycloalkyl is substituted by a cycloalkyl, or lower alkyl optionally substituted by CF 3; R 2 is hydrogen, lower alkyl, (CH 2)o - cycloalkyl, (CH 2)o -0- cycloalkyl, (CH 2)o - lower alkoxy, substituted by halogen (CH 2)o - lower alkoxy , (CH 2) optionally substituted by lower alkyl, o - heterocycloalkyl, (CH 2) o -S ( 0) 2 - cycloalkyl, lower alkyl, one or two optionally substituted by one or two hydroxy (CH 2 ) o -S (O) 2 -lower alkyl, lower alkyl substituted by halogen, or CH 2 CH (OH) CF 3 ; R <; 3 >; is halogen or lower alkyl; X is CH or N; X 1 is CH or N; n is 1 or 2; o is 0, 1, 2 or 3; m is 0, 1 or 2; The dotted line is a bond or not a bond. The compounds are useful for the treatment and / or prevention of schizophrenia, including both positive (psychotic) and negative symptoms of schizophrenia, drug abuse, alcohol and drug addiction, obsessive compulsive disorder, cognitive impairment, bipolar disorder, mood disorder, major depression, , Parkinson's disease, chronic pain, borderline personality disorder, sleep disorders, chronic fatigue syndrome, stiffness, anti-inflammatory effects in arthritis and certain central nervous system disorders that are impaired balance.본 발명은 하기 화학식 I의 2-옥소-2,3-다이하이드로-인돌뿐만 아니라 이의 약학적으로 허용가능한 염, 라세미 혼합물, 또는 이의 상응하는 거울상 이성질체 및/또는 광학 이성질체 및/또는 입체이성질체에 관한 것이다: I상기 식에서,Ar은, N, O 또는 S로부터 선택된 1, 2 또는 3개의 헤테로원자를 함유하는 헤테로아릴 기이고;R1은 수소, 저급 알킬, 할로겐, 아미노, 다이메틸아미노, 시아노, 할로겐에 의해 치환된
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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