您的位置: 首页 > 农业专利 > 详情页

ETHYNYL DERIVATIVES
专利权人:
에프. 호프만-라 로슈 아게
发明人:
비아이라 에릭,얘슈케 게오르크,구바 볼프강,리치 안토니오,뤼허 다니엘,비만즈 바르바라,플랑셰 장-마르크,오하라 피온
申请号:
KR1020167023095
公开号:
KR1020160111509A
申请日:
2015.02.24
申请国别(地区):
KR
年份:
2016
代理人:
摘要:
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or acid addition salt thereof, a racemic mixture, or a corresponding enantiomer and / or optical isomer and / or stereoisomer thereof: (I) In this formula, Y is N or CR &apos;; R 1 ' is hydrogen or F; R 1 is hydrogen, halogen, or lower alkyl substituted by halogen; R <; 2 >; is hydrogen or lower alkyl; R 2 together with R 4 form a 6-membered heterocyclic ring containing -CH 2 -CH 2 -O-CH 2 - or -CH 2 -CH 2 -NR-C (O) -, Lower alkyl, phenyl or benzyl; R <; 3 >; is phenyl or pyridinyl, the N atom in the pyridinyl group may be in different positions; R 4 ' is hydrogen, lower alkyl or lower alkoxyalkyl; R 4 is hydrogen, lower alkyl, phenyl optionally substituted by halogen, or lower alkoxy, or is cycloalkyl, pyridinyl optionally substituted by halogen, lower alkyl, lower alkoxy or ═O, or is lower alkyl, Pyridinyl, pyridinyl, pyridazinyl which is optionally substituted by lower alkyl, lower alkoxy or = O, or 1-methylpyrrolo [2 , 3-b] pyridin-5-yl, or 6-imidazo [l, 2-b] pyridazin-6-yl; R 4 together with R 4 ' represents - (CH 2 ) 5 -, -CH 2 -CH 2 -O-CH 2 -CH 2 -, -CH 2 -CH 2 -CH 2 -, -CH 2 -CH 2 - Form a 4-membered, 5-membered or 6-membered heterocyclic ring containing a group CH 2 -CH 2 -, -CH 2 -O-CH 2 -CH 2 - or CH 2 -CH 2 -CH 2 -O-CH 2 ; R 5 and R 5 ' are hydrogen or lower alkyl; R 4 together with R 5 form a saturated five-membered ring containing -CH 2 -CH 2 -CH 2 -. The compounds may be used for the treatment of Parkinson's disease, anxiety, vomiting, obsessive compulsive disorder, autism, neuroprotection, cancer, depression or type 2 diabetes.본 발명은 하기 화학식 I의 화합물 또는 이의 약학적으로 허용되는 염 또는 산부가 염, 라세미체 혼합물, 또는 이의 상응하는 거울상 이성질체 및/또는 광학 이성질체 및/또는 입체 이성질체에 관한 것이다:
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充