The present invention relates to a formulation able to increase the metabolism of the elder collagen protein inside dermis and the method of using thereof, including a first compound and a second compound. The first compound and the second compound are able to product precipitation between the compound and skin after mixing.本發明係一種可增加真皮層中老化膠原蛋白的代謝之配方及其使用方法,係包含一第一組合溶液及一第二組合溶液,且該第一組合溶液與該第二組合溶液混合時,係可在溶液及皮膚外層之間形成沉澱物。步驟(101)-步驟(103)係本發明可增加真皮層中老化膠原蛋白的代謝之配方之使用步驟