A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: A1 is CR6, A2 is CR7, and A3 is CR8 or A1 is CR6, A2 is N, and A3 is CR8； A4 is selected from a link, SO2, NR9, or O； L is selected from a bond, optionally substituted C 1-4 alkyl, C 3-6 cycloalkyl, C 3-6 heterocycloalkyl, or C 2-4 alkenyl； R1 is X-R16； X is a bond, or C1-2 alkyl； R16 is selected from the group consisting of C1-2 alkyl, cyclopentyl, cyclohexyl, piperidine, piperazine, morpholine, pyridine, pyrrolidine, cyclohexenyl, and tetrahydro-2H-pyran； wherein R16 is substituted with one to three groups selected from amino, hydroxyl, NHCH2-phenyl, CH2-amino, COO-t-butyl, H, methoxy, NH-SO2-ethyl, CH2-NHSO2-ethyl, SO2-ethyl, t-butyl, methyl, CH2-COOH, CONHCH3, CON (CH3) 2, NHC (CH3) -CH2-SO2-CH3, NH-COO-CH2-phenyl, hydroxy-methyl, CH2-NH-CH3, CH2-NH -ethyl, NH-CH2-CH2-methoxy, CH2-NH-CO-CH3, NH-CH2-CH2OH, NH-CO-CH2-N (CH3) 2. NH-COmethylpyrrolidine, NH-CH2-C (CH3) -dioxolane, NH-CO-pyridyl, NH-ethyl, pyrrolidine, CH2-NH-CO-pyridyl, NH-tetrahydropyran, COCH2-N (CH3) 2, NH-CH2 -C (CH3) - dimethyldioxolane, tetrahydropyran, CO-methylpyrrolidine, CH2-methylpiperidine, NH-CO-CH3, NH-SO2-CH3, NH-CH (CH2-OCH3) 2, NH-CH2-tetrahydrofuran, NHCH2-oxetane, NH-tetrahydropyran, NH-CH2-dioxane, N (CH3) -CH2CH2-OCH3, CH (OH) -CH2-amino, NHCH2CH2- OCF3, NHCH2-OCH3, NH-CH2-CH (CF3) -OCH3, NH-CH (CH3) -CH2-OH, F, NHoxetane, CH2-CH2-OCH3, CH2-OCH3, CH2-tetrahydropyran, CH2-methylpiperazine, NH2-CH2-CH (OH) -CF3, piperidine, CH2-pyrrolidine, NH-CH (CH3) CH2OCH3, NH-tetrahydrofuran, (CH2) 3-NH2, hydroxyethyl, propyl, CH2-pyridyl, CH2-piperidine, morpholine, NH-chloropyrimidine, NH-CH2CH2-SO2-methyl, (CH3) 3-N (CH3 ) 2, piperazine, ** Formula **Un compuesto de fórmula (I):**Fórmula** o una sal de este farmacéuticamente aceptable, en donde: A1 es CR6, A2 es CR7, y A3 es CR8 o A1 es CR6, A2 es N, y A3 es CR8； A4 se selecciona entre un enlace, SO2, NR9, u O； L se selecciona entre un enlace, a
