KUHNERT, SVEN,MERLA, BEATRIX,KLESS, ACHIM,BAHRENBERG, GREGOR,SCHRODER, WOLFGANG
申请号：
PE2011001596
公开号：
PE20120667A1
申请日:
2010.03.11
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to the derivative of 2-mercato-3-carbamate butyl (1), wherein R1 is tar (C1-C6),Cyclopropyl (C3-C10),Arilo, R2 is arilo or heterosexual, and is s (= O) 2, s (= O),- yes.- that is...Among others, R3, R4, R5, r6a, R6b, r7a, r7b, R8a and r8b are h, F, NO2, CF3, CN, ocf3 and tar (C1-C6), respectively,M is 0 or 1, among other things. The most popular compounds are n - [2 - [2 - [2 - (benzaldehyde) - ethyl sulfonamide] - pyridine-3-il] - 2-cyclohexane-acetamide； N - [2 - [[3 - (sulfur trifluoride) phenyl] sulfonamide] - acetamide] - pyridine-3-il] - sulfur-2-carboxyl； N - [2 - (3-phenyl-propylsulfonamide) - pyridine-3-ethyl-o-2-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl-ethyl. He also mentioned a pharmaceutical composer These compounds are the modulators of K + isomerization channels. The molecular structure of knk2 / 3 is used to treat pain, epilepsy, urinary incontinence and migrationSE REFIERE A COMPUESTOS DERIVADOS DE 2-MERCAPTO-3-AMINOPIRIDINAS DE FORMULA (1) DONDE R1 ES ALQUILO(C1-C6), CICLOALQUILO(C3-C10), ARILO, ENTRE OTROS； R2 ES ARILO O HETEROARILO； Y ES S(=O)2, S(=O), -S-, -O-, ENTRE OTROS； R3, R4, R5, R6a, R6b, R7a, R7b, R8a Y R8b SON CADA UNO H, F, NO2, CF3, CN, OCF3, ALQUILO(C1-C6), ENTRE OTROS； m ES 0 O 1. SON COMPUESTOS PREFERIDOS: N-[2-[2-(BENZOLSULFONIL)-ETILSULFANIL]-PIRIDIN-3-IL]-2-CICLOHEXIL-ACETAMIDA； AMIDA DE ACIDO N-[2-[2-[[3-(TRIFLUOROMETIL)FENIL]SULFONIL]-ETILSULFANIL]-PIRIDIN-3-IL]-TIOFEN-2-CARBOXILICO； N-[2-(3-FENIL-PROPILSULFANIL)-PIRIDIN-3-IL]-2-TIOFEN-2-IL-ACETAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL CANAL DE K+ HETEROMERICO DEL SUBTIPO MOLECULAR KCNQ2/3 SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR, EPILEPSIA, INCONTINENCIA URINARIA, MIGRANA
