A compound of formula I, wherein a is the reference CH2,-CH2-CH2-；Q is ch, N； R1 is C1-C6, alquenilo C2-C6, acquillo C2-C6, cloalquillo C3-C7； R2 is benzodiazepine, phenyl, sulfur, sulfur, substitution or not； R3 is trifluoride iodine, hydroxy, C1-C4, epoxy C3-C7, among others； R4 is phenyl, naftyl, hetrarillo, 5-10； deutero, substitution； R5 is non fluorine. Trifluoroide, C1-C4 tar, r29h, C1-C4 tar. The most popular compounds are: 2 - {3 - (4-chlorophenyl) - 5-oxo-4 - [(2 (s) - 3, 3, 3-trifluoro-2-hydroxypropyl] - 4, 5-dihydro-1h-1, 2, 4-trinitro-1 - {n} {2-nitro-1 - [3 - (sulfur trifluoride) phenyl} ethyl.3 - [(3 - (4-chlorophenyl) - 5-oxo-4 - [(2 (s) - 3, 3, 3-trifluoro-2-hydroxypropyl] - 4, 5-dihydro-1h-1, 2, 4-triazol-1-il} ethyl) amine] - 3 - [3 - (trifluoromethane) phenyl； and others. These compounds have dual antagonism to V1a / V2 receptor and are used to treat and / or prevent cardiovascular diseases.REFERIDA A UN COMPUESTO DE FORMULA I, DONDE A ES DE REFERENCIA -CH2-, -CH2-CH2-； Q ES CH, N； R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, CICLOALQUILO C3-C7 SUSTITUIDOS O NO； R2 ES BENZOTIENILO, FENILO, TIENILO, FURILO SUSTITUIDOS O NO； R3 ES TRIFLUOROMETILO, HIDROXILO, ALCOXI C1-C4, CICLOALCOXI C3-C7, ENTRE OTROS； R4 ES FENILO, NAFTILO, HETROARILO DE 5-10 MIEMBROS SUSTITUIDOS O NO； R5 ES H, DEUTERIO, TRIFLUOROMETILO, ALQUILO C1-C4； R29 H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: 2-{3-(4-CLOROFENIL)-5-OXO-4-[(2S)-3,3,3-TRIFLUORO-2-HIDROXIPROPIL]-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-1-IL}-N-{2-NITRO-1-[3-(TRIFLUOROMETIL)FENIL]ETIL}ACETAMIDA； CARBAMATO DE 3-[({3-(4-CLOROFENIL)-5-OXO-4-[(2S)-3,3,3-TRIFLUORO-2-HIDROXIPROPIL]-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-1-IL}ACETIL)AMINO]-3-[3-(TRIFLUOROMETIL)FENIL]PROPILO； ENTRE OTROS. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR V1a/V2 DE FORMA DUAL, UTILES EN EL TRATAMIENTO Y/O PREVENCION DE ENFERMEDADES CARDIOVASCULARES
