Refers to a compound of formula I, where a is the reference - CH2 -, - CH2 - CH2 - Q is CH, N r1 is alkyl of C1 - C6, alquenilo C2 - C6, alquinilo C2 - C3 - C7 C6, cycloalkyl substituted or unsubstituted phenyl, R2 is benzotienilo, tienilo, furilo replaced or not R3 is trifluoromethyl, Hydroxy, alkoxy c1-c4, moped Oalcoxi C3 - C7, among others R4 is phenyl, naphthyl,Hetroarilo 5-10 members replaced or not R5 is H, deuterium, trifluoromethyl, c1-c4 alkyl R29 h, c1-c4 alkyl.Preferred compounds are: 2 - (3 - (4-chlorophenyl) - 5 - oxo - 4 - [(2S) - 2 - hydroxypropyl) - trifluoro - dihydro - 4.5] - 1h-1,2,4-triazole - 1 - {il} - N - (2 - nitro - 1 - [3 - (trifluoromethyl) phenyl] ethyl} acetamide carbamate ({3 - [3 - (4-chlorophenyl) - 5 - oxo - 4 - [(2S) - 2 - hydroxypropyl) - trifluoro - dihydro - 4.5] - 1h-1,2,4-triazole - il - 1} Acetyl) amino] - 3 - [3 - (trifluoromethyl) phenyl] propyl among others.These compounds are antagonists of the Receptor V1a \/ V2 dual form, useful in the Treatment or prevention of cardiovascular diseasesREFERIDA A UN COMPUESTO DE FORMULA I, DONDE A ES DE REFERENCIA -CH2-, -CH2-CH2- Q ES CH, N R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, CICLOALQUILO C3-C7 SUSTITUIDOS O NO R2 ES BENZOTIENILO, FENILO, TIENILO, FURILO SUSTITUIDOS O NO R3 ES TRIFLUOROMETILO, HIDROXILO, ALCOXI C1-C4, CICLOALCOXI C3-C7, ENTRE OTROS R4 ES FENILO, NAFTILO, HETROARILO DE 5-10 MIEMBROS SUSTITUIDOS O NO R5 ES H, DEUTERIO, TRIFLUOROMETILO, ALQUILO C1-C4 R29 H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: 2-{3-(4-CLOROFENIL)-5-OXO-4-[(2S)-3,3,3-TRIFLUORO-2-HIDROXIPROPIL]-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-1-IL}-N-{2-NITRO-1-[3-(TRIFLUOROMETIL)FENIL]ETIL}ACETAMIDA CARBAMATO DE 3-[({3-(4-CLOROFENIL)-5-OXO-4-[(2S)-3,3,3-TRIFLUORO-2-HIDROXIPROPIL]-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-1-IL}ACETIL)AMINO]-3-[3-(TRIFLUOROMETIL)FENIL]PROPILO ENTRE OTROS. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR V1a/V2 DE FORMA DUAL, UTILES EN EL TRATAMIENTO Y/O PREVENCION DE ENFERMEDADES CARDI
