Relates to compounds of formula (IA) or (IB) where W is or sulfide X is Sulfur or,, N or amino (NRA) and Z is n or CH Hydroxy alkyl, cycloalkyl C1 - C3 - 20, 20, among others, u c, P, a - So - or Sulfur, phosphate t is o, N or CH l is o, sulfide, carbonyl, among others R1 and R2 are independent ... h, amino, Hydroxy, alkoxy C1 - 20, among others R3, R4, R5 and R6 are independently h,Halogen, Hydroxy, Nitrile, Nitro, among others R7, R8 and R9 are independently h, Nitrile, Nitro, trifluorometano, Alquiltio C1 - 20, among others m, N, P and q are independently 0, 1 or 2 R is 0, 1, 2, or 3, when - - \"-\" Its simple link: D, e and G are independently, E1, sulfide, or between Other and R10 is H, halogen, or, among others when \"-\" Double Link: D, e, E1, and GAre independently N or C - (RC) - functional Group and R10 is Sulfur or. Referring to a Pharmaceutical composition. These compounds inhibit the replication of the NS3 protease of hepatitis C virusSE REFIERE A COMPUESTOS DE FORMULA (Ia) O (Ib) DONDE: W ES O O SULFURO X ES O, SULFURO, N O AMINO (-NRa) Y ES N O CH Z ES HIDROXI, ALQUILO C1-20, CICLOALQUILO C3-20, ENTRE OTROS U ES C, P, SULFURO, -SO- O FOSFATO T ES O, N O CH L ES O, SULFURO, CARBONILO, ENTRE OTROS R1 Y R2 SON INDEPENDIENTEMENTE H, HIDROXI, AMINO, ALCOXI C1-20, ENTRE OTROS R3, R4, R5 Y R6 SON INDEPENDIENTEMENTE H, HALOGENO, HIDROXI, NITRILO, NITRO, ENTRE OTROS R7, R8 Y R9 SON INDEPENDIENTEMENTE H, NITRILO, NITRO, TRIFLUOROMETANO, ALQUILTIO C1-20, ENTRE OTROS m, n, p Y q SON INDEPENDIENTEMENTE 0, 1 O 2 r ES 0, 1, 2, O 3 CUANDO "----" ES ENLACE SIMPLE: D, E, E1 Y G, SON INDEPENDIENTEMENTE SULFURO, O, ENTRE OTROS Y R10 ES H, O, HALOGENO, ENTRE OTROS CUANDO "----" ES ENLACE DOBLE: D, E, E1 Y G, SON INDEPENDIENTEMENTE N O -C(RC)-GRUPO FUNCIONAL Y R10 ES SULFURO Y O. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA REPLICACION DE LA PROTEASA NS3 DEL VIRUS DE LA HEPATITIS C
