A non orthogonal cycle of five members containing nitrogen, replaced by bone or sulfur amide, serves as a modulator of the nuclear receiver of huerfano rorgama
GEGE, CHRISTIAN,KINZEL, OLAF,STEENECK, CHRISTOPH,KLEYMANN, GERALD,HOFFMANN, THOMAS
申请号：
PE2015000118
公开号：
PE20150463A1
申请日:
2013.05.29
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
It refers to heterocyclic compounds containing five members of nitrogen, which are substituted by (1) to (5) carbohydramines or sulfur amides, wherein R1, R2, R3, R4, R5 and R6 are defined in the description. The most popular compounds are: 1 - (3-bromo-5 - (TER butil) phenyl) - 5 - (cyclohexane-methanol-n) - 4-methyl-n - (tetrahydro-2h-piran-4-il) - 1h-pirol-3-carboxamida； acido 4 - (1 - (4 - (TER butil) sulfuric acid -) - 3 - (sulfur trifluoride) phenyl) - 5 - (cyclohexane) - 4-methyl-1-pirol-3-amino-ethyl-2, and other substances. He also mentioned a pharmaceutical composer These compounds are modulators of the nuclear receptor of huerphan rogamma and are useful in the treatment of rheumatoid arthritis,No suppurative sporitis, psychosis, asthmaSE REFIERE A COMPUESTOS HETEROCICLOS DE 5 MIEMBROS QUE CONTIENEN NITROGENO SUSTITUIDOS POR CARBOXAMIDA O SULFONAMIDA DE FORMULAS (1) A (5) DONDE R1, R2, R3, R4, R5 Y R6 SON COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: 1-(3-BROMO-5-(TER-BUTIL)FENIL)-5-(CICLOHEXILIDENMETIL)-4-METIL-N-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-PIRROL-3-CARBOXAMIDA； ACIDO 4-(1-(4-(N-(TER-BUTIL)SULFAMOIL)-3-(TRIFLUOROMETIL)FENIL)-5-(CICLOHEXILMETIL)-4-METIL-1H-PIRROL-3-CARBOXAMIDA)-2,2-DIMETILBUTANOICO； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR NUCLEAR HUERFANO RORgamma SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ESPONDILITIS ANQUILOSANTE, PSORIASIS, ASMA
