デュロキセチン塩基及びデュロキセチン塩酸塩の製造方法

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专利权人:

東和薬品株式会社

发明人:

助川 潤平,赤松 久,稲越 直人

申请号：

JP2015136244

公开号：

JP6182183B2

申请日:

2015.07.07

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide a high purity duloxetine base with suppressing a by-product having toxicity and suppressing generation of optical isomers and decomposition products and a method for manufacturing a duloxetine chlorinate.SOLUTION: There is provided a manufacturing method of duloxetine base including a process of mixing duloxetine alkyl carbamate, potassium hydroxide and toluene in the presence of lower alcohol and a process of heating and reacting the resulting mixture to distill away a part of solvent in reaction.SELECTED DRAWING: None

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/