SIYAN RAJINDER SINGH,GOHEL SUNILKUMAR VINUBHAI,BHISE NANDU BABAN,SINGH GIRIJ PAL
申请号：
IN1474/MUM/2014
公开号：
IN2014MU01474A
申请日:
2014.04.26
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a process for the preparation of duloxetine containing R-isomer less than 0.5 % by arylation of (S)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol with 1-fluoronaphathalene in presence of sodium amide and dimethyl sulfoxide.
