PROBLEM TO BE SOLVED: To provide a solid medicinal preparation ameliorated in dissolution tendency, through a simple process in terms of pharmaceutical manufacturing operation, as for such a medicament as to effect delay in disintegration and dissolution as a result of forming tacky gel layer on the surface of the medicament granules on contact with water.SOLUTION: A method for producing the solid medicinal preparation ameliorated in dissolution tendency is provided, comprising: coating, in layer(s), a water-soluble polymer solution dispersed/suspended with water-soluble or -insoluble additive microparticles on physiologically active substance granules forming tacky gel layer on the surface thereof on contact with water.COPYRIGHT: (C)2013,JPO&INPIT【課題】水との接触により粒子表面に粘着性のゲル層を形成し、崩壊、溶出が遅延する薬物について、製剤操作上簡便な方法により、溶出性が改善された固形製剤を提供すること。【解決手段】水との接触により粒子表面に粘着性のゲル層を形成する生理活性物質粒子に水溶性添加剤微粒子又は不溶性添加剤微粒子を分散懸濁した水溶性高分子溶液を単層もしくは複数層被覆することにより、溶出性が改善された固形製剤の製造方法を提供する。【選択図】図1
