PROBLEM TO BE SOLVED: To provide a solid preparation having an improved elution property by a method which is simple in formulating operation for a physiologically active substance having ultrahigh water solubility, forming an adhesive gel layer on the particle surface by contact with water, and delaying disintegration and elution.SOLUTION: There is provided the solid preparation including the physiologically active substance which is extremely readily soluble in water, and having an improved elution property without including a water-absorbing additive.COPYRIGHT: (C)2013,JPO&INPIT【課題】水溶性が極めて高く、水との接触により粒子表面に粘着性のゲル層を形成し、崩壊、溶出が遅延する生理活性物質について、製剤操作上簡便な方法により、溶出性が改善された固形製剤を提供すること【解決手段】水に極めて溶けやすい生理活性物質を含有し、吸水性添加剤を含ませないことにより、溶出性が改善された固形製剤を提供する。【選択図】なし
