CARDIOLIPIN-TARGETED PEPTIDES INHIBIT BETA-AMYLOID OLIGOMER TOXICITY

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专利权人:

Cornell University

发明人:

SZETO, Hazel H.,BIRK, Alexander,SZABO, Paul,ZHAO, Brian Yinge,REN, Margarita

申请号：

EP14848640

公开号：

EP3052115A4

申请日:

2014.09.29

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present disclosure provides aromatic-cationic peptides and methods of using the same. The methods comprise the use of the aromatic-cationic peptides in reducing the effects of toxic beta amyloid (Aβ) peptides including blocking the accumulation of extracellular Aβ oligomers, inhibiting Aβ-mediated oxygenase activity, reducing Aβ-induced mitochondrial dysfunction and/or preventing Aβ-induced neuronal apoptosis.

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中国工程科技知识中心

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