Zhao, Brian Yinge,Ren, Margarita,Szeto, Hazel H.,Birk, Alexander V.,Szabo, Paul
申请号:
AU2014324580
公开号:
AU2014324580A1
申请日:
2014.09.29
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present disclosure provides aromatic-cationic peptides and methods of using the same. The methods comprise the use of the aromatic-cationic peptides in reducing the effects of toxic beta amyloid (Aβ) peptides including blocking the accumulation of extracellular Aβ oligomers, inhibiting Aβ-mediated oxygenase activity, reducing Aβ-induced mitochondrial dysfunction and/or preventing Aβ-induced neuronal apoptosis.