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New acyl-piperazinones and their use as pharmaceutical products
专利权人:
FAB PHARMA SAS
发明人:
GERUSZ, VINCENT,ESCAICH, SONIA,OXOBY, MAYALEN,MOREAU, FRANCOIS
申请号:
ES10768235
公开号:
ES2483120T3
申请日:
2010.10.20
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (I): in which: - W, X and Y independently mean CH2 or C>; = O, wherein said CH2 group may be optionally substituted independently with a fluorine or an alkyl group- ( C1-C6), wherein said alkyl- (C1-C6) group may be further substituted with one or two R5 groups; - R1 means H, alkyl- (C1-C6) optionally substituted with a CONRaRb, alkenyl- (C2-C6), alkynyl- (C2-C6), phenyl or a -Z-Het group, so that Z means a binding or a linker selected from CO, alkylene- (C1-C6) or -CO-alkylene- (C1-C6), and Het means a 4- to 6-membered monocyclic heterocycle, saturated or unsaturated, containing 1 to 3 selected heteroatoms of N, O and S, wherein said phenyl group or heterocycle of R1 may be optionally substituted with one or multiple R5 group; - R2 means H, CO2Ra, CORa, CONRaRb, CH2ORc, CH2NRaRb, SO2NRaRb, or P (O) ORaORb; - R3 means halogen, alkyl- (C1-C6), alkenyl- (C2-C6) or alkynyl- (C2-C6); - R4 means H, halogen, CN or CH3; - Ra, Rb and Rc independently mean H, alkyl- (C1-C6), alkenyl- (C2-C6), alkynyl- (C2-C6), or an NRaRb group may optionally form a 3 to 7 membered saturated heterocycle which it contains nitrogen, which optionally contains 1 to 3 heteroatoms selected from N, O or S, wherein said heterocycle may be optionally substituted with one or multiple alkyl- (C1-C6) groups; - R5 means halogen, CN, alkyl- (C1-C6), alkenyl- (C2-C6), alkynyl- (C2-C6), CO2Ra, CORa, CONRaRb, OCORa, ORa, NRaRb, ON>; = CRaRb, NRcCORa, NRcCOORa, OCONRaRb, NRcCONRaRb, NRcSO2Ra, S (O) nRa, or SO2NRaRb; - n means an integer selected from 0 to 2; or a pharmaceutically acceptable salt or solvate thereofUn compuesto de fórmula (I): en la que: - W, X e Y significan, independientemente, CH2 o C>;=O, en donde dicho grupo CH2 puede estar opcionalmente sustituido de manera independiente con un flúor o un grupo alquilo-(C1-C6), en donde dicho grupo alquilo-(C1-C6) puede estar sustituido adicionalmente con uno o dos grupos R5; - R1 significa H, alquilo-(C1-C6) sustituido opciona
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