您的位置: 首页 > 农业专利 > 详情页

tricyclic triazole compounds as sigma receptor ligands
专利权人:
Laboratorios del Dr. Esteve; S.A.
发明人:
DIAZ-FERNANDEZ, José-Luis,ALMANSA-ROSALES, Carmen,CUEVAS-CORDOBES, Félix
申请号:
ES14720538
公开号:
ES2628818T3
申请日:
2014.04.21
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula (I) ** Formula ** in which R1 is selected from: - a group - (C (R3) 2) m-aryl, the aryl group being optionally substituted with at least one halogen atom; - a group - (C (R3) 2) m-heteroaryl the heteroaryl group may be optionally substituted with at least one substituent selected from a halogen, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkoxy or C1-3 haloalkyl and the heteroaryl group may be optionally condensed with an additional ring system; - a group - (C (R3) 2) n-heterocycloalkyl, the heterocycloalkyl may be optionally substituted with at least one substituent selected from a halogen, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkoxy or C1-3 haloalkyl and containing at least one oxygen atom; R2 is selected from: - a phenyl group optionally substituted with at least one substituent selected from a halogen, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 haloalkyl or a hydroxyl group; - a heteroaryl group optionally substituted with at least one substituent selected from a halogen, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 haloalkyl or a hydroxyl group; - a heterocycloalkyl group and which is optionally substituted with at least one substituent selected from a halogen, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 haloalkyl or a hydroxyl group; R3 is H or C1-3 alkyl; m is 1 to 3; and n is 0 to 3; with the proviso that when R1 is a group - (C (R3) 2) m-aryl, R2 is not a phenyl group; or a pharmaceutically acceptable salt or solvate thereof.Un compuesto de fórmula general (I)**Fórmula** en la que R1 se selecciona de: - un grupo -(C(R3)2)m-arilo pudiendo estar el grupo arilo opcionalmente sustituido con al menos un átomo de halógeno; - un grupo -(C(R3)2)m-heteroarilo pudiendo estar el grupo heteroarilo opcionalmente sustituido con al menos un sustituyente seleccionado de un halógeno, alquilo C1-3, alcoxi C1-3, haloalcoxi C1-3 o haloalquilo C1-3 y pudiendo estar el grupo heteroarilo opcionalmente condensado con un sistema de anillos adicional; - un grupo -(C(R
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充