HOGG, Joan Heather,KESTER, Robert Francis,LIANG, Weiling,YUN, Weiya
申请号：
ES13773766
公开号：
ES2623304T3
申请日:
2013.10.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I: ** Formula ** in which: W is selected from the group a) H, b) C1-6 alkyl optionally including 1-3 deuterium atoms, and c) C1-6 alkyl which may optionally be substituted with SO2R5 and OR5； Y is C1-6 alkyl which may be optionally substituted with OR5； Z is N； R1 is selected from the group a) C1-6 alkyl which may be optionally substituted with SO2R5, b) C3-7 cycloalkyl, c) heterocyclyl, and d) aryl； R2 is selected from the group a) H b) C (O) NHR6, c) heterocyclyl, and d) heteroaryl； R3 and R4 may be the same or different and each is independently selected from the group a) H, and b) C1-6 alkyl； R5 is selected from the group a) H, b) C1-6 alkyl, c) NR7R8, and d) aryl； R6 is selected from the group a) H, b) aryl which may be optionally substituted with C1-6 alkyl, OR5, halogen, C (O) OR5, C (O) NR7R8, aryl, heterocyclyl, C (O) R9, SO2R5 , cyano and CF3, c) C1-6 alkyl which may be optionally substituted with CF3, SO2R5 and aryl which may be optionally substituted with C1-6 alkyl and halogen, d) heteroaryl which may be optionally substituted with C1-6 alkyl, OR5 , halogen, aryl and oxo, and e) heterocyclyl； R7 and R8 may be the same or different and each is independently selected from the group a) H, b) C1-6 alkyl, and c) aryl； R9 is selected from the group a) C1-6 alkyl, and b) aryl； or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula I:**Fórmula** en el que: W se selecciona del grupo a) H, b) alquilo C1-6 que incluye opcionalmente 1-3 átomos de deuterio, y c) alquilo C1-6 que puede estar opcionalmente sustituido con SO2R5 y OR5； Y es alquilo C1-6 que puede estar opcionalmente sustituido con OR5； Z es N； R1 se selecciona del grupo a) alquilo C1-6 que puede estar opcionalmente sustituido con SO2R5, b) cicloalquilo C3-7, c) heterociclilo, y d) arilo； R2 se selecciona del grupo a) H b) C(O)NHR6, c) heterociclilo, y d) heteroarilo； R3 y R4 pueden ser iguales o diferentes y cada uno se selecciona independientemente del grupo a) H, y
