MACDONALD, GREGOR JAMES,DE BOECK, BENOÎT CHRISTIAN ALBERT GHISLAIN,LEENAERTS, JOSEPH ELISABETH
申请号：
ES10782609
公开号：
ES2549917T3
申请日:
2010.11.25
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound having the formula (I) ** Formula ** or a stereochemical isomer thereof, wherein R 1 is C 1-6 alkyl, C 1-6 alkyl substituted with 1, 2 or 3 halogen substituents, C 1-6 alkyl substituted with 1 cyano group, C1-6 alkyl, substituted with 1 heteroaryl group, C3-6 cycloalkyl, C3-6 cycloalkyl substituted with 1, 2, 3 or 4 methyl groups, C3-6 cycloalkyl substituted with 1 hydroxy group, (C3- cycloalkyl 6) C1-6 alkyl, (C1-6 alkyloxy) C1-6 alkyl, (C1-4 haloalkyloxy) C1-6 alkyl, tetrahydrofuryl, aryl, heteroaryl, pyrrolidinyl, pyrrolidinyl substituted with 1 C1-4 alkyl group, or substituted tetrahydrofuryl with 1, 2 or 3 substituents selected from methyl and oxo； aryl is 2,2-difluoro-1,3-benzodioxolyl； phenyl； or phenyl substituted with 1, 2 or 3 substituents selected from halogen, trifluoromethyl, trifluoromethoxy, cyano, C1-6 alkyl, C1-4 alkyloxy and aminosulfonyl； heteroaryl is an aromatic, monocyclic or bicyclic heterocyclic radical, containing at least one heteroatom selected from N, O and S, optionally substituted with 1, 2 or if possible with 3 substituents selected from C 1-4 alkyl, C 1-4 alkyloxy, C3-6 cycloalkyl and trifluoromethyl； R2 and R3 are independently H, C1-4 alkyl or trifluoromethyl； or R2 and R3 are taken together to form 1,2-ethanediyl or 1,3-propanediyl； Ar is R4 and R5 are independently H, C1-4 alkyl, trifluoromethyl, C3-6 cycloalkyl or C1-4 alkyloxy, or a salt by the addition of acids thereof, or a solvate thereof.Un compuesto que tiene la fórmula (I)**Fórmula** o un isómero estereoquímico del mismo, en donde R1 es alquilo C1-6, alquilo C1-6 sustituido con 1, 2 ó 3 sustituyentes halógeno, alquilo C1-6 sustituido con 1 grupo ciano, alquilo C1-6, sustituido con 1 grupo heteroarilo, cicloalquilo C3-6, cicloalquilo C3-6 sustituido con 1, 2, 3 ó 4 grupos metilo, cicloalquilo C3-6 sustituido con 1 grupo hidroxi, (cicloalquil C3-6)alquilo C1-6, (alquiloxi C1-6)alquilo C1-6, (haloalquiloxi C1-4)alquilo C1-6, tetrahidrofurilo, arilo, heteroarilo, pi
