Shigeyuki Tanifuji,Akio Hayashi,Daisaku Nakamura,Shinya Takasaki,Anthony Eamon Storey,Denis Raymond Christophe Bouvet
申请号：
US12308715
公开号：
US08277777B2
申请日:
2007.06.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A compound that has affinity with amyloid, exhibits sufficiently rapid clearance from normal tissues, and is suppressed in toxicity such as mutagenicity is provided, which is represented by the following formula (1):or a salt thereof,wherein R1 is a group selected from hydrogen, hydroxyl group, carboxyl group, sulfate group, amino group, nitro group, cyano group, an alkyl substituent with one to 4 carbon atoms or an alkoxy substituent with one to 4 carbon atoms R2 is a radioactive halogen substituent and m is an integer of 0 to 2, and a low-toxic diagnostic agent for Alzheimers disease comprising a compound represented by the above formula or a salt thereof is also provided.
