DÉRIVÉ DE N2,N4-DIPHÉNYLPYRIMIDINE-2,4-DIAMINE, SON PROCÉDÉ DE PRÉPARATION, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT COMME PRINCIPE ACTIF POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER

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专利权人:

Korea Research Institute of Chemical Technology

发明人:

申请号：

EP18816671.4

公开号：

EP3640246A1

申请日:

2018.06.12

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention relates to a N2,N4-diphenylpyrimidin-2,4-diamine derivative, a method for preparing the same, and a pharmaceutical composition for the prevention or treatment of cancer, containing the same as an active ingredient. The derivative shows a relatively weak EGFR activity inhibitory effect on wild-type EGFR, a high inhibitory ability on EGFR mutation, and a high inhibitory ability on even FLT3 and FLT3 mutation, and thus, can be effectively used for the treatment of cancer with EGFR mutation or cancer with FLT3 or a mutation thereof, and the derivative shows a synergy effect at the time of combination administration, and thus can be effectively used for the treatment of combination administration.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/