N2,N4-DIPHENYLPYRIMIDINE-2,4-DIAMINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER
Kwangho Lee,Inji Shin,Gildon Choi,Chong Hak Chae,Hyeon Jeong Choe,Myoung Eun Jung,Byeong Uk Jeon,Byoung Chul Cho,Chae Won Park,Hwan Kim,Krishna Babu Duggirala
申请号：
US16622057
公开号：
US20200179384A1
申请日:
2018.12.06
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a N2,N4-diphenylpyrimidin-2,4-diamine derivative, a method for preparing the same, and a pharmaceutical composition for the prevention or treatment of cancer, containing the same as an active ingredient. The derivative shows a relatively weak EGFR activity inhibitory effect on wild-type EGFR, a high inhibitory ability on EGFR mutation, and a high inhibitory ability on even FLT3 and FLT3 mutation, and thus, can be effectively used for the treatment of cancer with EGFR mutation or cancer with FLT3 or a mutation thereof, and the derivative shows a synergy effect at the time of combination administration, and thus can be effectively used for the treatment of combination administration.
