N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
The present invention relates to a N2,N4-diphenylpyrimidine-2,4-diamine derivative, a method for preparing same, and a pharmaceutical composition containing same as an active ingredient for the prevention or treatment of cancer. The derivative shows a relatively weak EGFR activity inhibitory effect on wild-type EGFR, high inhibitory ability on EGFR mutation, and high inhibitory ability on even FLT3 or FLT3 mutation, and thus can be favorably used in the treatment of cancer with EGFR mutation or cancer with FLT3 or mutation thereof, and the derivative shows a synergy effect at the time of combinative administration, and thus can be favorably used in the treatment of combinative administration.
