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METODO OPTIMIZADO PARA DESCONTAMINAR EL ALMIDON USADO COMO MATERIA PRIMA PARA OBTENER POLIMEROS DE GLUCOSA PARA DIALISIS PERITONEAL.
专利权人:
ROQUETTE FRERES
发明人:
Fabrice ALLAIN,Pierre LANOS,Thierry DUPONT,Mathieu CARPENTIER,Hela HACINE-GHERBI,Agnes DENYS
申请号:
MX2017015429
公开号:
MX2017015429A
申请日:
2016.06.03
申请国别(地区):
MX
年份:
2018
代理人:
摘要:
The present invention concerns a method for decontaminating the starches used as a raw material for the preparation of glucose polymers intended for peritoneal dialysis, the method comprising the following steps: - preparing a Waxy corn starch, - placing the Waxy starch in suspension at a concentration of between 20 and 40% dry matter in a process water at a pH of between approximately 5 and approximately 6, in particular approximately 5.5, - treating the starch suspension with a peracetic acid solution at a concentration equal to or between 100 and 500 ppm, preferably 300 ppm, - dewatering the starch, then dissolving in demineralised water adjusted to a pH of between approximately 5 and approximately 6, in particular approximately 5.5 and at a concentration of between 20 and 40% dry matter, - increasing the temperature to 107 °C, then adding an alpha-amylase for 15 minutes, - optionally, treating with an enzymatic preparation having detergent and clarification properties, - filtering the suspension on a bed of diatoms, - treating with an active carbon having a very high adsorption capacity, of pharmaceutical quality, and of "microporous" porosity, - treating with a second active carbon of "mesoporous" porosity, - optionally, passing over a macroporous adsorbent polymer resin, having a porosity greater than 100 angstroms, - optionally, continuous 5000 Da ultrafiltration, - safety filtration through a sterile filter having a porosity of 0.22 µm.La presente invención se refiere a un método para descontaminar los almidones usados como material de partida para la preparación de polímeros de glucosa destinados a diálisis peritoneal, comprendiendo el método las siguientes etapas: - preparación de un almidón céreo de maíz, - ubicación del almidón céreo en suspensión a una concentración entre 20 y un 40% de materia seca en agua del proceso a un pH entre aproximadamente 5 y aproximadamente 6, en particular de aproximadamente 5.5, - tratamiento de la suspensión de almidón con
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