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Zoptymalizowany sposób dekontaminacji skrobi stosowanej jako surowiec do otrzymywania polimerów glukozy do dializy otrzewnowej
专利权人:
Roquette Freres
发明人:
LANOS, PIERRE,DUPONT, THIERRY,ALLAIN, FABRICE,CARPENTIER, MATHIEU,HACINE-GHERBI, HÉLA,DENYS, AGNÈS
申请号:
PL16741056
公开号:
PL3303409T3
申请日:
2016.06.03
申请国别(地区):
PL
年份:
2020
代理人:
摘要:
The present invention concerns a method for decontaminating the starches used as a raw material for the preparation of glucose polymers intended for peritoneal dialysis, the method comprising the following steps: —preparing a Waxy corn starch, —placing the Waxy starch in suspension at a concentration of between 20 and 40% dry matter in a process water at a pH of between approximately 5 and approximately 6, in particular approximately 5.5, —treating the starch suspension with a peracetic acid solution at a concentration equal to or between 100 and 500 ppm, preferably 300 ppm, —dewatering the starch, then dissolving in demineralised water adjusted to a pH of between approximately 5 and approximately 6, in particular approximately 5.5 and at a concentration of between 20 and 40% dry matter, —increasing the temperature to 107° C., then adding an alpha-amylase for 15 minutes, —optionally, treating with an enzymatic preparation having detergent and clarification properties, —filtering the suspension on a bed of diatoms, —treating with an active carbon having a very high adsorption capacity, of pharmaceutical quality, and of “microporous” Porosity, —treating with a second active carbon of “mesoporous” porosity, —optionally, passing over a macroporous adsorbent polymer resin, having a porosity greater than 100 angstroms, —optionally, continuous 5000 Da ultrafiltration, —safety filtration through a sterile filter having a porosity of 0.22 μm.
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