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OPTIMISED METHOD FOR DECONTAMINATING THE STARCH USED AS A RAW MATERIAL FOR OBTAINING GLUCOSE POLYMERS INTENDED FOR PERITONEAL DIALYSIS
专利权人:
ROQUETTE FRÈRES
发明人:
PIERRE, LANOS,THIERRY, DUPONT,FABRICE, ALLAIN,MATHIEU, CARPENTIER,HÉLA, HACINE-GHERBI,AGNÈS, DENYS
申请号:
TR201910239
公开号:
TR201910239T4
申请日:
2016.06.03
申请国别(地区):
TR
年份:
2019
代理人:
摘要:
The present invention concerns a method for decontaminating the starches used as a raw material for the preparation of glucose polymers intended for peritoneal dialysis, the method comprising the following steps: - preparing a Waxy corn starch, - placing the Waxy starch in suspension at a concentration of between 20 and 40% dry matter in a process water at a pH of between approximately 5 and approximately 6, in particular approximately 5.5, - treating the starch suspension with a peracetic acid solution at a concentration equal to or between 100 and 500 ppm, preferably 300 ppm, - dewatering the starch, then dissolving in demineralised water adjusted to a pH of between approximately 5 and approximately 6, in particular approximately 5.5 and at a concentration of between 20 and 40% dry matter, - increasing the temperature to 107 °C, then adding an alpha-amylase for 15 minutes, - optionally, treating with an enzymatic preparation having detergent and clarification properties, - filtering the suspension on a bed of diatoms, - treating with an active carbon having a very high adsorption capacity, of pharmaceutical quality, and of "microporous" porosity, - treating with a second active carbon of "mesoporous" porosity, - optionally, passing over a macroporous adsorbent polymer resin, having a porosity greater than 100 angstroms, - optionally, continuous 5000 Da ultrafiltration, - safety filtration through a sterile filter having a porosity of 0.22 μm.Mevcut buluş, periton diyalizine yönelik amaçlanan glukoz polimeri preparatına yönelik bir hammadde olarak kullanılan nişastaların dekontaminasyonuna yönelik bir yöntem ile ilgilidir, yöntem, aşağıdaki adımları içerir: - bir Waxy mısır nişastasının hazırlanması, - yaklaşık 5 ile yaklaşık 6 arasında bulunan, özellikle yaklaşık 5,5 olan bir pH değerinde bir proses suyu içinde kuru maddenin %20'si ile 40'ı arasında bulunan bir konsantrasyonda Waxy nişastasının süspanse edilmesi, - 100 ile 500 ppm arasında bulunan, tercih edildiği
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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