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OPTIMISED METHOD FOR DECONTAMINATING THE STARCH USED AS A RAW MATERIAL FOR OBTAINING GLUCOSE POLYMERS INTENDED FOR PERITONEAL DIALYSIS
专利权人:
ROQUETTE FRERES
发明人:
LANOS, Pierre,DUPONT, Thierry,ALLAIN, Fabrice,CARPENTIER, Mathieu,HACINE-GHERBI, Héla,DENYS, Agnès
申请号:
FRFR2016/051325
公开号:
WO2016/193634A1
申请日:
2016.06.03
申请国别(地区):
FR
年份:
2016
代理人:
摘要:
The present invention concerns a method for decontaminating the starches used as a raw material for the preparation of glucose polymers intended for peritoneal dialysis, the method comprising the following steps: - preparing a Waxy corn starch, - placing the Waxy starch in suspension at a concentration of between 20 and 40% dry matter in a process water at a pH of between approximately 5 and approximately 6, in particular approximately 5.5, - treating the starch suspension with a peracetic acid solution at a concentration equal to or between 100 and 500 ppm, preferably 300 ppm, - dewatering the starch, then dissolving in demineralised water adjusted to a pH of between approximately 5 and approximately 6, in particular approximately 5.5 and at a concentration of between 20 and 40% dry matter, - increasing the temperature to 107 °C, then adding an alpha-amylase for 15 minutes, - optionally, treating with an enzymatic preparation having detergent and clarification properties, - filtering the suspension on a bed of diatoms, - treating with an active carbon having a very high adsorption capacity, of pharmaceutical quality, and of "microporous" porosity, - treating with a second active carbon of "mesoporous" porosity, - optionally, passing over a macroporous adsorbent polymer resin, having a porosity greater than 100 angstroms, - optionally, continuous 5000 Da ultrafiltration, - safety filtration through a sterile filter having a porosity of 0.22 μm.La présente invention est relative à un procédé de décontamination des amidons utilisés comme matière première pour la préparation de polymères de glucose destinés à la dialyse péritonéale, le procédé comprenant les étapes suivantes : - préparation d'un amidon de maïs Waxy, - mise en suspension de l'amidon Waxy à une concentration comprise entre 20 et 40 % de matière sèche dans une eau de process à un p H compris entre environ 5 et environ 6, en particulier environ 5,5, - traitement de la suspension d'amidon par une solution d
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